How does the substance in Cialis (Tadalafil) work?

 Effectiveness Results

5mg tablet

Effects of tadalafil on erectile function

시알리스  given at doses of 2.5 mg, 5 mg and 10 mg once daily was evaluated in 3 clinical studies involving 853 patients of various age groups (21 to 82 years) and ethnicities, with varying degrees of etiology. and severity of erectile dysfunction (mild, moderate and severe). In the two main efficacy studies in the general population, 76 and 85% of patients reported that tadalafil given once daily improved erection, compared to 29 and 30% of patients in the placebo group. In addition, patients in all erectile dysfunction severity categories reported improved erection while taking tadalafil once daily. In the pivotal efficacy studies, 62 and 69% of the study population treated with tadalafil 5 mg were successful in sexual intercourse attempts, compared to 34 and 39% of the placebo group.

Effects of tadalafil on signs and symptoms of benign prostatic hyperplasia

시알리스 구매 administered at a dose of 5 mg once daily was evaluated in 2 clinical studies involving 749 patients over 45 years of age (40% over 65 years of age) with signs and symptoms of Benign Prostatic Hyperplasia (BPH); and 1 clinical study involving 408 patients with symptoms of BPH and associated erectile dysfunction. The primary endpoint in all 3 studies was improvement in the International Prostate Symptom Index (IPSS) after 12 weeks of treatment, with statistically significant improvement (p<0.005) being demonstrated for the use of tadafil 5 mg compared with placebo in BPH symptoms at the end of this period.

Efficacy in erectile dysfunction of patients with diabetes mellitus

시알리스 구입  given once daily has been shown to be effective in treating erectile dysfunction in patients with diabetes. Patients with diabetes were included in all 7 primary efficacy studies with the general population with erectile dysfunction (N=235) and one study that specifically evaluated tadalafil only in diabetic patients (Type 1 or Type 2) with erectile dysfunction (N=216) . A randomized, multicenter, double-blind, placebo-controlled, parallel-arm study demonstrated consistent and statistically significant clinical improvement in erectile function in diabetic patients with the use of tadalafil administered once daily.

20mg tablet

Study design

The efficacy and safety of tadalafil in the treatment of erectile dysfunction were evaluated in 22 clinical studies of up to 24 weeks duration. The studies involved more than 4,000 patients, with dosages from 2 to 100 mg taken as needed, up to once daily. Tadalafil has been shown to be effective in improving erectile function in men with erectile dysfunction (ED).

Various assessment instruments were used to study the effect of tadalafil on erectile function. Global Assessment Questions (GAQ) were asked to determine whether the treatment improved patients' erections. During clinical studies, patients and their partners completed Sexual Encounter Profile (PES) diaries, assessing erectile function and satisfaction with each sexual attempt. The International Index of Erectile Function (IIFE) was also completed by the patients. The IIFE provides global measures of erectile function and sexual satisfaction, as well as the severity of ED.