A remedy for hypertension

The birth of 비아그라 판매  occurred in a curious way. Pfizer was conducting a trial of a high blood pressure drug and decided to stop it, but when he asked study participants to return their leftover pills, many refused. The explanation was not that they had solved their hypertension problems, but something quite different: thanks to the preparation, these men were experiencing erections that many hardly even remembered.

Pfizer's reaction was immediate. He immediately put the idea of ​​using the drug against hypertension on hold and began working on making it a remedy for impotence. To do this, it was necessary to ensure that what had been a secondary effect until then became the main effect and vice versa.

Million-dollar investments and almost five years of work bore fruit, and on March 27, 1998, Pfizer obtained approval from the United States Food and Drug Administration (FDA) for its product, sildenafil citrate, which was marketed as a blue, diamond-shaped pill-bearing the name 비아그라 판매  (referring to "vigor" and "Niagara").

Viagra was not the first effective remedy against impotence, but it offered two great advantages over others: it was comfortable to use and it only caused an erection when there was sexual stimulation.

The end of punctures

Until then, the treatment against impotence consisted fundamentally of applying a vasodilator to the penis, through a puncture with a small syringe similar to those used by diabetics, or by inserting a suppository through the urethra. If this did not take effect, the use of mechanical means such as vacuum pumps, in which the patient inserts the penis to, by pumping the air, create a vacuum that causes the blood to flow and the erection arises, or prostheses , which are inserted into the penis by surgery and provide a continuous semi-erection, sufficient for penetration.

These remedies have been proving their worth for years, but they are much more cumbersome and unpleasant than taking a simple pill. In addition, the erections they cause are purely mechanical, regardless of whether the man feels desire or not, something that does not happen with Viagra, one of whose advantages is precisely that it acts by restoring the body's natural response to a sexual stimulus , so that if it does not exist, the erection does not occur. This is possible thanks to the fact that sildenafil does not directly cause an erection but instead enhances the action of nitric oxide (NO), the molecule responsible for transmitting orders for vascular dilation to the penis when sexual arousal occurs.

Side effects

비아그라 판매  begins to work about an hour after taking it and lasts for four to five hours. The FDA recommended dose is 50 milligrams per day, although doses of 100 milligrams can be administered in certain cases; and it is advisable to take a maximum of one pill on alternate days.

Its side effects, although generally mild, include headaches, digestive discomfort, facial flushing or vision changes, ranging from blurred vision to perceiving things with a bluish tint and difficulty in distinguishing green from blue, discomfort that can last several hours. It can also cause blood pressure drops, so its use is especially contraindicated for those who take compounds with nitroglycerin to treat heart conditions.

In fact, the association of sildenafil with heart medicines has caused numerous scares and even deaths. The first deaths were known when the famous blue pill had been on the market for less than a month, and caused some mistrust in the midst of the euphoria. The company Pfizer and the FDA then opened investigations that revealed that the deceased were men over 40 years old, diabetic, hypertensive, with high cholesterol levels and suffering from heart disease.

In view of these data, the FDA did not consider it necessary to modify the safety profile of the drug, although the warnings about its use were redoubled, starting by reminding that it is a drug to treat impotence, not to increase performance sexual, and emphasizing the risks of combining Viagra with nitrate-based treatments such as those prescribed to combat heart disease.