Cialis for erectile dysfunction: dosage and prescription

Introduction: what is Cialis?

Image that represents a person with a model of the prostate in front of himCialis is a drug used for the treatment of erectile dysfunction , i.e. the inability to obtain or maintain a penile erection sufficient to have sexual intercourse . Sexual stimulation is required for Cialis to be effective for the treatment of erectile dysfunction. Cialis can also be used for urinary symptoms associated with a common condition called benign prostatic hyperplasia

This condition occurs when the prostate enlarges with age. Symptoms include difficulty starting urination, a feeling of not completely emptying the bladder, and a more frequent need to urinate even during the night. Cialis improves blood flow and relaxes the muscles of the prostate and bladder , which can reduce symptoms associated with benign prostatic hyperplasia. Cialis has been shown to improve these urinary symptoms as early as 1-2 weeks after starting treatment .

시알리스 구매 is indicated in adultsfor the treatment of WHO functional class II and III pulmonary arterial hypertension (PAH), in order to improve the ability to exercise. Efficacy has been demonstrated in idiopathic pulmonary arterial hypertension (IPAH) and pulmonary arterial hypertension associated with collagen vascular disease .

The active ingredient contained in Cialis is Tadalafil , which belongs to the class of phosphodiesterase type 5 inhibitor drugs . After sexual stimulation, tadalafil allows the relaxation of the blood vessels in the corpus cavernosum of the penis allowing the flow of blood and consequent erection.

It should be noted that Cialis will not help in the absence of erectile dysfunction.

Cialis can be prescribed with RR Recipe - prescription medicines.

Cialis is available in coated tablets in three different strengths:

•     2.5 mg
•     5 mg
•     10 mg of active ingredient (tadalafil).

Dosage: how does Cialis work and how is it used?

Erectile dysfunction

Image representing blue padsTadalafil belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors, which also includes Sildenafil (the active ingredient in Viagra). Type 5 phosphodiesterase is an enzyme that can hydrolyze a substance called cyclic GMP (cyclic guanosine mono phosphate or cGMP). It is present in the smooth muscle of the corpus cavernosum of the penis, visceral and vascular smooth muscle, skeletal muscle , platelets , kidneys , lungs and cerebellum .

Le cellule del corpo cavernoso del pene producono ossido nitrico (NO) che, durante l’eccitazione sessuale, stimola la formazione di GMP ciclico. Un aumento di GMP ciclico nella muscolatura liscia provoca un rilassamento delle fibre muscolari con conseguente vasodilatazione. Il trattamento con un inibitore della fosfodiesterasi di tipo 5 aumenta la quantità e la permanenza del NO in loco e quindi prolunga e accentua questo rilassamento.

L’effetto del tadalafil è più potenteon PDE5 than on other phosphodiesterases. Tadalafil is 10,000 times more potent for PDE5 than for PDE1, PDE2 and PDE4, enzymes that are present in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac contractility.

Tadalafil has a longer duration of action than sildenafil and this allows for a single daily administration.

ATTENTION: Always take 시알리스 구매 following your doctor 's instructions carefully . If in doubt, consult your doctor or pharmacist. The tablets should be taken orally , regardless of food intake. If you forget to take the dose of cialis, take the dose as soon as you remember , but do not take a double dose to make up for the forgotten tablet. Do not take Cialis more than once a day.

Adult men

In general, the recommended dose is 10 mg taken before anticipated sexual activity and regardless of meals.

In those patients in whom a 10 mg dose of tadalafil does not produce an adequate effect, a 20 mg dose may be tried.

The medicine can be taken at least 30 minutes before sexual activity .

Do not exceed once daily administration.

시알리스 구매 10 mg and 20 mg should only be used firstof anticipated sexual activity and are not recommended for continuous daily use.

In patients anticipating frequent use of Cialis (e.g., at least twice a week) it may be advisable to dosing once daily with the lowest dosages ( e.g. 5 mg taken once daily at approximately the same time of the day), based on the patient's choice and the doctor's judgment. The dose can be decreasedto 2.5 mg once daily based on individual tolerability. The appropriateness of continued use of the daily dosing schedule should be reassessed periodically .

•     Dosage adjustment is not required in the elderly , diabetics and patients with mild to moderate renal impairment .
•     In patients with severe renal impairment, the maximum recommended dose is 10 mg as needed, although administration is not generally recommended.
•     In patients with hepatic impairment, the recommended dose is 10 mg taken before anticipated sexual activity. 
•     In patients with severe hepatic impairment, a careful risk-benefit assessment by the prescribing physician should be performed on a case-by-case basis.

BPH

The dose is one 5 mg tablet to be taken once a day at approximately the same time of day. In case of benign prostatic hyperplasia and erectile dysfunction, the dose remains one 5 mg tablet to be taken once daily . 

Pulmonary arterial hypertension

Pulmonary arterial hypertension is associated with an insufficient release of nitric oxide from the vascular endothelium and consequent reduction of cGMP concentrations within the pulmonary vascular smooth muscle. PDE5 is the predominant phosphodiesterase in the pulmonary vessels . Inhibition of PDE5 by tadalafil increases cGMP concentrations resulting in relaxation of the smooth muscle of the pulmonary vessels and vasodilation of the pulmonary vascular bed. In pulmonary arterial hypertension the recommended dose is 40 mg (2x20 g) taken once daily, with or

Without food .

Overdose : Single doses up to 500 mg have been administered to healthy subjects, and multiple daily doses up to 100 mg have been administered to patients. Adverse events were similar to those seen at lower doses . In the event of an overdose, necessary standard supportive measures should be taken. Hemodialysis contributes negligibly to the elimination of tadalafil .