Effects of tadalafil on erectile function

In all studies, tadalafil demonstrated consistent and statistically significant improvement compared to placebo across all primary and secondary endpoints evaluated. The treatment effect did not diminish with time. Tadalafil, at doses from 2 to 100 mg, has been evaluated in 16 clinical studies involving 3,250 patients, including patients with erectile dysfunction of various levels of severity (mild, moderate and severe), etiologies (including patients with diabetes), ages (21 to 86 years), ethnicity, and duration of erectile dysfunction. In primary efficacy studies of general populations, 81% of patients reported that tadalafil improved their erections. Also, ED patients across all severity categories reported better erections while taking tadalafil (86%, 83%, and 72% for mild, moderate, and severe, respectively).

시알리스 구매 Tadalafil showed statistically significant improvement in patients' ability to achieve an erection sufficient for intercourse and to maintain an erection for satisfactory intercourse, as measured by ESP diaries. In primary efficacy studies, 75% of attempts at intercourse were successful in patients treated with tadalafil.

Tadalafil also demonstrated statistically significant improvement in erectile function as measured by the IIFE Erectile Function Domain. Additionally, in primary efficacy studies, at the 20 mg dose, approximately 60% of patients treated with tadalafil achieved normal erectile function during treatment.

response period

Three clinical studies were conducted in 1054 patients in a home environment to define the period of response to tadalafil. Tadalafil demonstrated statistically significant improvement in erectile function and in the ability to have satisfactory sexual intercourse up to 36 hours after dosing, as well as in patients' ability to achieve and maintain erections for satisfactory intercourse, compared to the placebo group, starting at 30 minutes. after the dose.

Patient confidence and sexual satisfaction

The IIFE also measures the confidence that patients can achieve and maintain an erection sufficient for sexual intercourse. Tadalafil improved patient confidence in a statistically significant way. Analysis of the IIFE Sexual Relationship Satisfaction and Global Satisfaction domains showed that treatment with tadalafil results in a statistically significant increase in sexual satisfaction, as measured by both domains. Additionally, tadalafil improved the proportion of sexual encounters that were satisfactory for the patient and his partner.

Efficacy in erectile dysfunction of patients with diabetes mellitus

시알리스 구입 Tadalafil is effective in treating erectile dysfunction in patients with diabetes. Patients with diabetes (N=451) were included in all primary efficacy studies, one of which specifically evaluated tadalafil only in diabetic patients (Type 1 or Type 2) with erectile dysfunction. Tadalafil produced statistically significant improvement in erectile dysfunction and sexual satisfaction. In these studies, 68% of patients with diabetes treated with tadalafil at a dose of 20 mg reported improved erections.

Efficacy in erectile dysfunction of patients who underwent radical prostatectomy

시알리스 Tadalafil has been shown to be effective in treating patients who have developed erectile dysfunction due to bilateral nerve-sparing radical prostatectomy. In a randomized, placebo-controlled, double-blind, parallel, prospective study in this population (N=303), tadalafil demonstrated a clinically significant improvement in erectile function, with 62% of patients reporting improved erections with the use of tadalafil 20 mg .