Tadalafil / Cialis - essence and features

Tadalafil is a medicine used to treat erectile dysfunction in men (impotence). It is sold worldwide under the trade name 시알리스 or Tadalafil. It is also used to treat the initial signs and symptoms of benign prostatic hyperplasia (BPH). It is available in the form of pills and is a powerful sexual stimulant . There is also 시알리스 - oral gel . Many exercisers take it as it makes them stronger and more durable .

Nature and composition of Tadalafil: Tadalafil is a carboline-based compound with vasodilator activity. It selectively inhibits cyclic guanosine monophosphate (cGMP), a precursor of specific phosphodiesterase type 5 (PDE-5). It is located in the smooth muscle of the cavernous tissue. Taking Tadalafil leads to prolonged muscle relaxation, vasodilation and blood flow to this tissue. With its help, an erection of the penis is achieved.

Tadalafil (Tadalafil) - pill for the weekend

Features of Tadalafil: Tadalafil is a stronger substitute than Viagra which gives better results. The distinctive pharmacological feature of Tadalafil is its longer half-life (17.5 hours) compared to Viagra and Levitra (4-5 hours). This longer period results in a longer duration of action and is partly responsible for Tadalafil's nickname - the "weekend pill" .

Action / effect when taking Tadalafil / Tadalafil

The exact mechanism of Tadalafil has not been established. It has been shown to result in decreased nerve activity and increased smooth muscle relaxation and tissue perfusion of the prostate and bladder. It does not directly cause penile erection, but affects the response caused by sexual stimulation.

  • Helps with erection problems;
  • Stabilizes blood and completely regulates blood circulation;
  • Makes exercisers stronger and more durable;
  • Strengthens muscles and speeds up metabolism;
  • Gives more tone and concentration;

How does Tadalafil work? The physiological mechanism of penile erection involves the release of nitric oxide (NO) into the cavernous tissue during sexual stimulation. NO then activates the enzyme guanylate cyclase, leading to smooth muscle relaxation and blood flow to the cavernous tissue.

Tadalafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for the breakdown of cGMP. When sexual stimulation causes local NO release, inhibition of PDE-5 by tadalafil causes increased levels of cGMP, leading to smooth muscle relaxation and blood flow to the penis. The increased blood flow causes a stronger erection for a long period of time. At recommended doses of 시알리스, it has no effect in the absence of sexual stimulation.

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